The RNAi pathway is mediated by short double-stranded RNA oligonucleotides called “small interfering RNAs” or “siRNAs.” To date, efforts aimed at harnessing this pathway to silence disease-causing proteins have used double-stranded siRNAs. Using its expertise in oligonucleotide chemistry and design, Isis has discovered strategies for designing single-stranded oligonucleotides that act through the RNAi mechanism. With further development, these chemically modified, single-stranded, RNA-like oligonucleotides could have improved properties for systemic administration while harnessing certain advantages of the RNAi mechanism.
Explore open source software hotspots around the world through the interactive Open Source Index, or OSI, based on research by the Georgia Institute of Technology (Georgia Tech). The OSI is a measure of the open source activity and environment in 75 countries. Each country is given a score based on its policies, practices, and other data in the fields of Government, Industry, and Community. The leader? France.