Pharma Strategy Blog

Commentary on Pharma & Biotech Oncology / Hematology New Product Development

Posts tagged ‘ASCO’

It’s that time of the year again where we cogitate and contemplate on what might be hot at the annual meeting of the American Society of Clinical Oncology (ASCO) before the abstracts are available (they’re released online tomorrow at 6pm ET).

This year, while interesting early data from up and coming small biotechs is likely to be eagerly presented in poster sessions, the focus is more likely going to be on big Pharma with various phase III and also late phase II trials that are due to report data.  Unfortunately, not all of these will produce overwhelmingly positive results though!

What I’m most interested is things that shift the needle meaningfully  in terms of survival by six months or more, as we saw from the recent BOLERO2 and CLEOPATRA trials in ER+ and HER2+ breast cancer.  There are plenty of agents that offer minor or incremental improvements (colon cancer has long suffered from that syndrome, sadly), but let’s be honest – most of us get excited by the possibility of major shifts in survival.

Please note that I’ve mostly selected some promising agents in development that might achieve that effect, explained why they are different and focused on new data/drugs rather than rehash what I call the ‘middlings’ i.e. minor upgrades to the standard of care.

Without much further ado, here are my ASCO preview highlights for 2012:

Please do check back during the convention both here on PSB, and also on Biotech Strategy, for reports and analysis as the interesting data emerges at ASCO.

If you have any comments or thoughts, please do share them below…

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Many of you will remember PSB reader Dr Al Lalani of Regeneron’s guest blog post around this time last year with a quick summary of the key clinical trials at the American Society of Clinical Oncology (ASCO) meeting based on the study acronyms, which turned out to be highly popular.

Fortunately, Al has kindly sent in a review of this year’s trials in a very creative fashion, as you can see below (PSB: Thanks, Al!).

I strongly suggest that it is of PARAMOUNT importance that you all either check out these key acronyms in the abstracts when they go live on Wednesday to add to your ASCO schedule, or for the more enthusiastic participants, you play acronym bingo as you complete the daily #blisterwalk and make your way round the sessions in Chicago…


The annual ASCO prep work gears up this week in preparation for the online release of full abstracts this week.

You may recall my PSB guest post on the prevalent use of acronyms from last year’s conference.

It seems that some seem to be prepping for ASCO12 in unusual ways:

Dr Al Lalani, Regeneron

ASCO 2012 Acronymania, courtesy Dr Al Lalani

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Today brings us the annual American Society of Clinical Oncology (ASCO) breast cancer symposium from San Francisco.

ASCO Breast Cancer Symposium 2011Sadly I’m not attending due to other commitments, but there will likely be a number of people there who will be tweeting the event. The official hashtag #BCS11 so it seemed a great opportunity to keep track of them for everyone interested in easily reading them all in one place.

You can click on the conference widget below at any time and follow the conversation from attendees and those remote from San Francisco:

I’m not expecting any earth shattering or breaking news on the therapy and new product development pipeline front (based only on the presentation titles), although some interesting discussions may evolve on more immediate and practical aspects from the program, such as:

For those interested, the breast cancer symposium abstracts are now available and searchable online.

This latest widget captures all the tweets and discussion about ASCO data including the week before the meeting – this year the tweets are going at a tremendous velocity, with a much wider variety of people joining in.

Check it out below:

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It’s that time of year again and boy, does the annual meeting of the American Society of Clinical Oncology (ASCO) come round all too quickly! It’s almost like Battime, Batplace…

As usual, I’ll be aggregating the conference tweets using the official #asco11 hashtag, so that all of you not going to the event can follow along remotely – do feel free to join in the conversation and ask questions or post comments using #asco11 on Twitter:

 

 

This widget will run for the duration of ASCO until close of play on Wednesday, so do check back regularly for new tweets and conversation!

Next Thursday, I’ll be at the European Hematology Association (EHA) meeting in London, so a new tweet aggregator will be added then.

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On Sunday, I was delighted to receive an email from a regular Pharma Strategy Blog reader, Dr Al Lalani, a scientist who works at Regeneron.

Like many of us, Al waded through this year’s 5,000 or so abstracts for the upcoming annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago and noticed some interesting trends. He was particularly struck by the number of acronyms in use this year and put together a thoughtful and most amusing summary, which he has agreed to let me post here on PSB as today’s awesome guest post.

Clinical trial acronymania is alive and well at 2011 ASCO

Back in grad school, I recall being amused by the quirky names anointed to freshly cloned Drosophila genes like hedgehog, cactus and lava lamp. Fast-forward fifteen years and now I’m equally tickled about the curious acronyms given to late stage clinical trials.

A quick scan at this year’s ASCO abstracts and you’ll know what I mean.

There’s the MIMOSA trial and the FOxTROT, both of which deserve 10 points for ingenuity since neither study evokes images of Sunday brunch cocktails or ballroom dancing, in my opinion. Then comes the bevy of Avastin studies like AVAGAST, AVANT, AVAglio, AVAPERL, and BEVLiN.  Pure Roche branding genius.

Several gentler, feminine names including MARIANNE, EMILIA and SOFIA appear expectedly for trials in women with breast cancer.

If this is starting to sound a wee bit poetic, well you may want to consider checking out the updates from both POETIC and PROSE in this year’s Trials in Progress Session.

There are also the lofty and inspirational sounding studies like PYRAMID, TRIUMPH and RADIANT-3, or the self-assured ones such as RESILIENCE, PARAMOUNT, EXPERT-C and PREDICT.

Can’t decide on which orientation? Try either the LANDSCAPE or PANORAMA studies.

Feeling like it’s almost beach weather? How about the OCEANS, CALYPSO or TROPIC trials? The SORBET study may help to cleanse the palette after all this nonsensical acronymania.

And finally, leave it to the Spaniards to name an adjuvant lung cancer trial, SCAT.

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Today, I’ll be heading off to Orlando to the Genito-Urinary Cancer meeting co-hosted by ASCO, ASTRO and SUO and runs through Saturday. This year promises to have some interesting data coming out on a variety of cancers, including renal cell and prostate cancers.

The official hashtag is #gusymposium, which is unfortunately rather long, when you consider there are only 140 characters for a tweet and medical meetings tend to contain a lot of complex information to parse on the fly. Like many, I’ll be using #ascoGU, which is much simpler and shorter when tweeting in a hurry. The widget below captures both to make following remotely easier.

If you have any questions, do tweet me @maverickny and I’ll do my best to answer them. ASCO also have a Twitter handle (@asco) if anyone has any logistics queries.

By popular request, we are now rolling out the PSB conference newsletter.

This will be an occasional event that will be sent out after some scientific meetings we’ve attended.  They will contain snippets and summaries of data or new drug classes that we found interesting and worth highlighting and will be an adjunct to the blog, so you won’t get the same things twice 🙂

The first one will roll out by the end of this week and cover last week’s meeting from AACR on colorectal cancer biology.

You can sign up in the side bar on the top right —->

If you are a subscriber for this blog, you still need to opt-in to receive the newsletter. Sorry for the inconvenience, but personally, I hate it when people use my email address to send me things I didn’t request, so the same courtesy is extended to every one here too.

If you wish to stop receiving the newsletter, you can easily unsubscribe with 1-click.

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Getting back to the blogging groove after 3 weeks on the road at successive conferences (AUA, ASCO and EHA) is a bit of a shock, so the first post will be short and pithy.

AUA will be remembered for incredibly unsocial and early 6am education session starts.  No thanks, with three meetings in a row stamina trumps insanity by a long shot.  At ASCO, the Chicago venue is sprawling with long walks between sessions that appear to have no theme or cohesion around them and of course, the Press Room is way out in left field over the walkway no matter where you need to go.  The S406 Vista Room was particularly bad and became notorious for the #blisterwalk on Twitter.  Never again will I complain about switching between Halls A and F at Orlando, that's a piece of cake by comparison!

The second big difference I noticed between US and EU meetings was the presence or absence of chotchkes.  In the US they are now verboten of course, but the EU has no such constraints.

Now, I'm not sure a branded laptop sleeve or a Post-it pad ever made a difference to prescribing habits, but well done journal reprint carriers with a clear summary of the data do make a difference in oncology.  They help reinforce the efficacy, survival curves and key messages to your audience.

One thing I particularly remember most from EHA was a very well done piece that clearly differentiated the brand from the competitor, with data I hadn't noticed before.  Talking to some of the hematologists, they were equally interested in the pieces too as they included a peer reviewed journal reprint.  Some were taking copies back to share and discuss the data with their colleagues, which I found interesting.  What's going to have more impact – a branded item with no message or a clinical paper?

The Roche booth was particularly busy whenever I visited the exhibits.  The reason?  Great espresso coffee and the best quality nibbles, much appreciated early in the morning and late afternoon by drooping attendees.  I was less enthused by the aggressive ladies on the stand who wouldn't let me play with the interactive education quizzes for a USB key because the press passes didn't have a bar code on them.  I desperately needed a USB key to share a file with a physician.  We both walked away from that with a negative impression that overrode the nice refreshments.  A little flexibility goes a long way.

The other neat thing at the European Hematology Association meeting in Barcelona was a CD of many of the biology and clinical posters.  Great stuff, saves hours of work trying to piece together snippets taken on an iPhone!

Perhaps my favourite thing about European meetings, aside from the relaxed sociable hours with time to network with people, was the integration and inclusion of the patient advocate voice.  Critical, but largely ignored in American meetings.  More on this in another post.

This week I'll be putting up some synopses of data found interesting from the meetings, but the analyses may well be very different from what you saw in the news items.  Some of the reporting at ASCO in particular was sketchy puff pieces or hype at best, with very little real understanding of what the data actually means.

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As with previous meetings, I'm aggregating the ASCO tweets using three key hashtags: 

#asco10 (the official twitter hashtag) 

#asco2010 (some people are using this) 

#ascopress (for press alerts)

The stream should be live as of 3pm CST and will run for the duration of the meeting until COB on Tuesday:


Ready, Steady, Go!

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