Do foetal stem cells cause cancer?

By MaverickNY on February 18, 2009

There have been a number of studies, including some from Steven Goldman's lab in Rochester, NY, showing that injecting embryonic stem cell transplants in rats for various neurological conditions such as Parkinson's disease can lead to undifferentiated growth, ie tumours.

It therefore came as no surprise to read in PLoS Medicine this morning that an Israeli group has reported a similar finding in a teenager who was treated for ataxia telangiectasia with somatic foetal cells injected in his brain and spinal cord.

The boy received three courses of foetal stem cell injections to the brain and the fluid surrounding the spine. Four years after his first injection he was investigated for
recurrent headaches and his doctors in Tel
Aviv found two tumours – one in the spine and one in the brain – at the
same sites the injections had been given.

A year later, the doctors removed the
non-cancerous tumour from his spine and it was found to contain cells
that could not have arisen from the patient's own tissue and had in all
probability grown from the donated stem cells. In fact, microsatellite and HLA analysis demonstrated that the tumor was derived from at least two donors.

The authors concluded that:

"The findings here suggest that neuronal stem/progenitor cells may be
involved in gliomagenesis and provide the first example of a
donor-derived brain tumor."

My take home from all this?

There is a body of research clearly demonstrates that foetal stem cells are very unstable and can lead to undifferentiated cell growth and cancer, so caution and further animal research is most likely warranted to determine how best to utilise both foetal and embryonic stem cell technology. Adult stem cells are much more stable and may offer a better way forward in the short term.

Sources:

Ninette Amariglio, Abraham Hirshberg, Bernd W. Scheithauer, Yoram Cohen, Ron Loewenthal, Luba Trakhtenbrot, Nurit Paz, Maya Koren-Michowitz, Dalia Waldman, Leonor Leider-Trejo, Amos Toren, Shlomi Constantini, Gideon Rechavi (2009). Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient PLoS Medicine, 6 (2) DOI: 10.1371/journal.pmed.1000029

Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal, Steven A Goldman (2006). Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes Nature Medicine, 12 (11), 1259-1268 DOI: 10.1038/nm1495

6 Responses to “Do foetal stem cells cause cancer?”

Alexey February 18, 2009

Sally,
those cells from PLoS Med paper, transplanted in boy, are not embryonic stem cells, they are fetal neural tissue (somatic) cells. I even can’t call them “stem” (they don’t have signature to earn this name) – it’s basically mash up of brain tissue (i assume there are some progenitor cells which still could divide few times) of aborted fetus (fetus = after 12 weeks). Embryonic stem cells finalize their existence on week 2-3 of gestation age (blastocyst = about 200 cells).
So this case report is unique and it’s hard to extrapolate to adult stem cell transplantation and ESC-derivates trials. But we definitely must be alarmed.
Also this transplant case was not in “clinical trial” settings, so cell quality of graft and service was not regulated by government organs like FDA.
Sally Church February 18, 2009

Alexey, good catch! I wrote it in a hurry while multi-tasking and will make the change to foetal cells.
To be fair though, there have been reports of benign cancers and stem cells in animals in the literature so I think caution is definitely advised.
phyl franklin March 4, 2009

Stem Cell Enhancers: The NEW Science
Standing singly, away from all the controversy, some of the scientific community is giving rise to the world’s very first patented, organic stem cell enhancer. With only a single dose of this modern day amazement your body can begin the renewal process. In fact, within just one hour after taking this wonder supplement, three to 4 million, yes MILLION stem cells are added to your bloodstream and go to work.
StemEnhance is a revolutionary breakthrough, all natural product that supports adult stem cell physiology. It’s the first patented product on the market in the latest phytoceutical category called “Stem Cell Enhancers”.
Standing singly, away from all the controversy, some of the scientific community is giving rise to the world’s very first patented, organic stem cell enhancer. With only a single dose of this modern day amazement your body can begin the renewal process. In fact, within just one hour after taking this wonder supplement, three to 4 million, yes MILLION stem cells are added to your bloodstream and go to work.http://www.phyl247.com or http://www.phyl247.biz phyl247 970-985-4076
Yasser Moh'd Kurdi March 20, 2009

O.K people : I think you are an American group, or an American,Neurological Scientists,concerned with the treatment of,M.S. My name is Yasser M.Kurdi,and M.S,started with me 5,(maybe)6,years ago.At the beginning,I used to limp,on my left leg,and to manage to walk,using a cast. But since early,or mid 2006,I became unable to walk totally.I have used Copaxone,that I used to get from Israel,for a period of time.In Amman,Jordan where I live,and at the M.S society group,patients use, “Interfirone”.So that’s it, I became unable to walk since a time,(month),in 2006. I do’nt believe M.S, is curable,still I can get medications,through the Ministry of Health,in Amman.I 49 years old,I regret to say,I left my Job.Now,I also take antidrepssants. Bye Yasser M.Kurdi
Killing cancer cells with human embryonic stem cells | Pharma Strategy Blog October 26, 2010

[…] Do embryonic stem cells cause cancer? (pharmastrategyblog.com) This entry was posted in Cancer, Cell Therapy, Market Trends, Strategy, Technology and tagged competitive intelligence, KOL market research, oncology cancer, pharmaceutical biotechnology marketing strategy consulting, social media monitoring. Bookmark the permalink. ← links for 2009-05-05 Genentech’s Avastin approved for Glioblastoma → blog comments powered by Disqus /* […]
Natural energy February 28, 2011

Thanks for Nice bog.I like the detailed information on natural energy.
sharing this information.I’ll share it with others.

Comments are closed.