A new study published in the American Journal of Hematology Oncology by the Children's Oncology Group demonstrated that the ABVE-PC regimen provided high efficacy and reduced the cumulative doses of chemotherapy and radiation:
For years, patients have been treated with the standard of care, ie MOPP or ABVD regimens, but while these approaches lead to excellent survival rates, they often result in long-term effects from toxicity, including infertility, second malignancy, and cardiopulmonary toxicity. Doctors hope to be able to cure the cancer while reducing the risk of long term effects on patients with the new 6 drug combination, although it will take a while before the true effects are known.
This new approach consists of doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide and while not a walk in the park, as the first four chemotherapies are fairly toxic themselves, it may represent a potential improvement for children with NHL over existing options.
Schwartz, C., Constine, L., Villaluna, D., London, W., Hutchison, R., Sposto, R., Lipshultz, S., Turner, C., deAlarcon, P., & Chauvenet, A. (2009). A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate and high risk Hodgkin lymphoma: the results of P9425 from the Children's Oncology Group Blood DOI: 10.1182/blood-2008-10-184143
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