Pharma Strategy Blog

Commentary on Pharma & Biotech Oncology / Hematology New Product Development

Posts from the ‘Social Media’ category

It’s the end of a long week and today I thought it would be nice to highlight some people who write about cancer in the blogosphere since some people have emailed asking me what blogs do I read.

Here are a few cancer news sources I enjoy each week – some are writers, some survivors, some physicians, some analysts and not all have blogs, but some use other social media tools creatively to aggregate useful cancer information.

I heartily suggest you check them all out – their linked names take you to their Twitter stream and the other link to their blog or social media resource:

  1. Jody Schoger: Women with Cancer
  2. Alicia Stales: Awesome Cancer Survivor Blog
  3. Dr. Jack West: GRACE – expert mediated discussions on cancer esp. lung cancer
  4. Matthew Herper: Forbes Health
  5. Adam Feuerstein: The Street
  6. Dr. Len Lichtenfeld (ACS): Dr Len’s Blog
  7. Dr. Elaine Schattner: Medical Lessons blog
  8. Dr. Anas Younes: Curates an awesome Facebook page with regular cancer news
  9. Dr. Wafik El Diery: Has a superb cancer daily on Paper.li that I read each morning on my Flipboard
  10. Dr. Ray DuBois and Dr Naoto Ueno from MD Anderson and Dr Robert Miller from Johns Hopkins also share lots of interesting cancer news in their Twitter streams

There are many others, but I’ll stop there for this week and add a few more in the next update.

Disclosure: I am an unpaid member of the GRACE board.

Who do you enjoy reading and why?  If you have any other suggestions, please do include them in the comments below.

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Yesterday heralded was the first of six four-hour poster sessions here at the American Association for Cancer Research (AACR) meeting.   Nearly 5,000 posters are being presented here in total, which makes for a lot of shoe leather running round the vast exhibit hall!

As my colleague pointed out on Biotech Strategy Blog, choosing one out of many interesting ones is a highly subjective matter.  He chose one on nanotechnology, an area that he has a keen interest in.

My selection for Poster of the Day is perhaps a little unusual.   In the patient advocacy session, Leslie Hammersmith’s stood out as a brilliant example of how to use social media really well at a scientific meeting.

What did I like about her approach?

1) She used Twitter to let people know she was presenting and drew attention to scientists like me to check out the poster (good marketing!).

2) The poster is simply and elegantly designed, making it easy to read for tired eyes, as mine were after a very long day.

3) The use of QR codes for references and supporting materials as well as a card handed out to enable downloading of the poster via a QR code was novel and interesting.

4) Loved the title: “Poke, Tweet, Tag, Share: A new generation of Cancer Advocacy”

The clever use of QR codes made me want it on all the science posters too, both for easy downloads instead of handouts, and links to references.   In terms of innovation and creativity, this poster won hands down for me.  Nice job, Leslie!

For those of you hankering to see the poster yourselves, check out the card below using your QR reader and see for yourself:

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Yesterday was a travel day for many of us at AACR and the weather doesn’t always cooperate in ensuring timely arrivals.  Never fear, there are ways to catch up on what was missed…. wondering what was hot on Day 1?  Check out the short video clip below:

AACR have posted their webcast and podcasts links for those following remotely that are worth checking out – many are free as well, making them great value.

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Today is Friday and I try to post something lighthearted and fun at the end of a busy week.  With that in mind, someone sent me this great link to Kids Kicking Cancer.  As someone who experienced a childhood cancer, I can identify with this awesome concept – help the kids feel victors not victims:

Kids Kicking Cancer

They have some great use of social media tools to spread their message and provide links to inspiring stories about the Kids.  There is a Facebook Page and a YouTube channel, for example.  After watching one of their their videos, I simply couldn’t resist sharing a genuine feel-good story about what their vision is:

“Kids Kicking Cancer uses martial arts breathing, meditation and imagery techniques to ease the pain of very sick children while empowering them to heal physically, spiritually and emotionally.

Our mantra of “Power Peace Purpose” allows the children to know that they are victors not victims. In turn they teach adults, corporations and other children how to control stress, pain, fear and anger.

When they hear from the Hollywood superstars that “you boys and girls are the real heroes” it helps them to recognize that they really do have the enormous power to bring themselves to an inner healing peace.”

Check out this short inspiring video and spread a little happiness…

Many of us live busy stressful lives and forget to nurture the spirit and mindfulness to decompress from the hurly burly of life.  I was therefore really pleased to see that there is also a an iPhone app and Blackberry app that are worth checking out for breathing exercises to manage stress for everyone, not just kids, as well.  Do check them out and share them with your family and friends!

Some light hearted amusement for today is in order after the levity and gravity of the weekend.   One of my favourite Twitter buddies, Robert Scoble (@scobleizer) the tech geek, is always sharing cool stuff for people to try.  I noticed he posted a link to a new social media beta service, mirror.me, which creates a tag cloud of a user’s tweets.

Robert’s tag cloud looks like this, for example:

To create your tag cloud, simply go to mirror.me and authenticate the service using your Twitter username and password.  It then creates the graphic automatically, with the most commonly used words in a bigger font size.

Here’s my tag cloud as another example:

As other people join, it will also show your Twitter connections with their avatar (photo) and their tag clouds as they are created.  Very useful tool for seeing what people’s interests are and, presumably, something that will change organically if your tweets vary over time.

The tool will also show you some basic metrics, such as information about your followers and what their interests are based on their Twitter bio tags.  I was guessing that most of mine would come from the healthcare space:

Mirror.me metrics

Your results may vary depending upon your interests and followers.

There are other metrics you can look at as well, such as rankings within your interests, but I’m not sure how this works yet:

mirror.me rankings

This feature is a little weird – some famous biotech companies are ranked lower than me and a bot tweeting people’s resumes is at the top of the biotech category, for example! That certainly gave me a smile for the morning 🙂

The good news is that mirror.me tweeted that they will be adding more features over time, so it should be a useful feature to follow and explore.

 

 

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SpringPad is a new free tool I’ve recently been playing with and it has quickly become a way to sort and organise information easily. In the past, I’ve been a big Evernote fan, but while it is useful for collecting abstracts, photos, papers etc, SpringPad has a whole different set of utilities that I find myself using on a daily basis, both in the office and while mobile at conferences.

One of the challenges in my work is sifting through vast amounts of data and generating useful insights, either for posts here on this blog or as a consultant. I’ve tried a lot of different web 2.0 tools over the last 7 years but occasionally one comes along that sticks in my workflow. SpringPad is one of them.

The first thing I did after signing up was download the iPhone app and the web clipper for Chrome, my preferred browser. This makes life a lot easier when you come across anything interesting:

SpringPad Web Clipper

You can also email items such as webpages, links and PDF files to SpringPad.

Once in the SpringPad web app (similar layouts for the iPhone are available in an app too), your top level notebooks appear something like this:

SpringPad Notebooks

You can colour code them for easy visual appeal and finding things. I’ve also hidden the mission critical client projects, but you can see the general gist of what my recent science topics looks like.

The nice thing about this approach is that you can create Notebooks by topics and then once you’ve clipped or emailed relevant information to SpringPad, it can be organised efficiently.

For example, the JP Morgan Healthcare conference is ongoing this week with lots of useful snippets emerging by company, drug and pathway.   I can clip, then tag the information and also assign it to several Notebooks.  Information emerging from the meeting on Keryx’s perifosine might get added to the Keryx, colorectal cancer and myeloma Notebooks, for example.  This makes it easier to find information later when you search for it, or later look at all the information you have collected to date on say, lung cancer or a particular pathway, to look at the big picture trends. I also diligently tag items across a broad range of topics so they will appear later in the database searches.

Another useful feature of SpringPad is that you can collate information around an event.

Once inside a notebook, for example, the recent one I created for the ISGC meeting at MD Anderson to keep me organised with a one stop shop for all the preconference information, to-dos and post conference notes looked like this:

SpringPad Notebook

While travelling to this meeting, I had everything I needed for the event in the iPhone app and could add new notes, to dos, places, contacts etc while on the road for other projects. This worked really well, even on the plane, since SpringPad will sync the notes once internet access is available later.

The iPhone is small so it is not good for rapidly note taking at meetings and wifi was gippy at best, so I made most of the notes on my Mac laptop in Twitter using a hashtag and also in an offline text app, Notational Velocity, which syncs with Simplenote. I’m now looking to see if I can email my notes on each presentation to SpringPad or worst case scenario, cut/paste them into the notes created. Another way to do this efficiently would be to use an iPad, but that’s still on my wish list in the Gear Notebook 🙂

Assigning dates to To-Dos and items is a really useful feature – you can check your Alert box and see what’s immediately due.

Another feature I like is the ability to import Delicious bookmarks (I have 3,000 of them!) as well as the associated tags, so these are now searchable in the context of any other information I might have collated in SpringPad. When a client rings up or sends an email asking about something, this makes the scientific, commercial or clinical answer much easier to find than Googling and getting lots of spammy results, which seems de rigeur in public searches of late.

There’s a lot more functionality in SpringPad not covered in this review, but I will add more updates as it becomes more familiar and a bigger database is built up. Has anyone else tried SpringPad yet? If so, what were your experiences or do you have any cool tips to share?

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I am always trying to find novel ways to use social media and new marketing channels to engage blog readers and distribute content, so for the princely sum of $0.99 a month you can now read Pharma Strategy Blog on your Kindle.

If you have a Kindle and would like the convenience of reading Pharma Strategy Blog offline at your leisure, on a bus or airplane, I hope you will think about signing up. Amazon offer a 14 day free trial.

Please click on the link below or on the right hand side sidebar to subscribe. I look forward to hearing from you as to whether this proves to be a successful way to deliver content.

On Thursday this week I’m off to the GI Carcinogenesis meeting hosted by MD Anderson Cancer Center, you can find out more about the event here.

It’s a brand new meeting for me, but according to the program:

“The ISGC is comprised of basic, translational and clinical scientists.  This conference will encourage and develop research and communication in the areas of gastroenterological biology and oncology in both basic and clinical aspects through joint meetings with international and national gastroenterologists.”

I’m particularly looking forward to hearing what Lee Ellis has to say on cancer stem cells and the microenvironment, as well as Emanuel Petricoin on molecular profiling in GI cancers.  There are a whole host of other really interesting talks too, as you can see from the program agenda.

When I first looked at the faculty, my initial reaction was, “Oh my!” It’s a quite serious line-up of some of the top GI cancer researchers and certainly not easy to get them all in the same place together, so it will be fun to chat with them in the poster sessions and get their perspective on the latest happenings in this field.

The meeting runs through Saturday, so I’ll try and post a daily synopsis, as time permits.

If I hadn’t been following Dr Raymond DuBois, the MD Anderson Provost and Co-Chair of the meeting on Twitter, I would have missed this altogether – the power of social media in spreading and communicating awareness of these special events is very much here to stay.

If you have any burning questions in this area, please do add them in the comments below and I will do my best to ferret out some answers.

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This morning I was delighted to see that one of my favourite medical doctors on Twitter, Dr Anas Younes from MD Anderson, has published a paper in the New England Journal of Medicine on a clinical trial of a promising new agent in development for a particular type of lymphoma.

Dr Younes is very active in social media on Twitter and Facebook and has garnered quite a following of lymphoma patients interested in learning about new treatments for the disease.   This also means that patients and caregivers following him are able to find out about new clinical trials as they open up.  MD Anderson Cancer Center probably has access to more clinical trials across all tumour types than any other cancer center, offering lots of options for cancer patients to receive novel therapies that may help their condition.   Another benefit of a physician being involved with social media is that awareness of the trials will reach more people this way and hence probably accrue faster.

What’s new in Hodgkins Lymphoma?

Before we discuss the NEJM paper, the other side of social media is that MD Anderson also use it to communicate the results of their trials on the Institution website and Dr Younes also has a nice video for patients, explaining how the drug works, about the trial and the results that they found.

Now, this was a phase I trial so normally we wouldn’t expect to see too much from an efficacy standpoint, as the main goal of these studies is to assess the range of toxicities and determine the maximum tolerated dose (MTD) for phase II trials, which look at the efficacy signal in more detail.

That said, what Dr Younes and his colleagues found was quite impressive responses in a disease that has not seen much in the way of new treatments for more than a decade.

It should be noted that the agent targets CD30 antigen that is expressed on Hodgkin Lymphoma and anaplastic large-cell lymphoma (ALCL) cells.  Previous attempts to target the CD30 antigen with monoclonal-based therapies have shown minimal activity.  What’s different about this new agent is that it is an antibody-drug conjugate (ADC), with an anti-CD30 monoclonal antibody linked to monomethyl auristatin E (MMAE), an anti-cancer agent.

The drug they were evaluating, brentuximab vedotin (SGN-35), from a partnership between Seattle Genetics and Millennium, elicited complete responses (CR) or partial responses (PR) in 38% of the patients with Hodgkin Lymphoma (HL).  In the NEJM article it boldly stated that:

“The median duration of response was at least 9.7 months. Tumor regression was observed in 36 of 42 patients who could be evaluated (86%).”

Looking at the data in the article, what was amazing was that there were 17 objective responses (38%), 11 of which (25%) were complete remissions, which essentially means disappearance of all evidence of the disease.  In addition, CT scans showed that 36 of 42 (86%) of evaluable patients saw their tumours shrink.

What’s next?

Overall, I think these very promising results raise hopes that the phase II trial will also produce positive results at the American Society of Hematology (ASH) in December, which will be really great news for patients with Hodgkin Lymphoma.

If the phase II results also look positive, then we can probably expect Seattle Genetics and Millennium to file in the first half of 2011.

ResearchBlogging.org Younes, A., Bartlett, N., Leonard, J., Kennedy, D., Lynch, C., Sievers, E., & Forero-Torres, A. (2010). Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas New England Journal of Medicine, 363 (19), 1812-1821 DOI: 10.1056/NEJMoa1002965

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This year I'm participating in the 14th Annual Cycle for Life on Saturday 11th September, which benefits the Floating Hospital for Children's Cancer Center. The basic idea is that the fundraising from the riders provides direct support for young patients and their families.

The organisation is based at Tufts Medical Center and offers a unique approach, which appeals to me:

"The pediatric cancer program at Floating Hospital for Children offers complete hematology and oncology services for children.  Floating Hospital physicians have developed novel protocols for the aggressive treatment of cancer, including autologous bone marrow transplantation and new approaches to administering chemotherapy.

Floating Hospital for Children's Cancer Center stresses a team approach to the management of pediatric cancer patients, working closely with pediatric surgeons and radiation oncologists.  The Center has received national recognition for its innovative patient and family support programs and provides state-of-the-art cancer treatment."

Source: Cycle for Life

Cycle for life Over the last couple of years, my Twitter buddy Alicia Staley has organised a team and off they go in their free time one Saturday morning in the fall, 25 or 50 miles round Marblehead, Massachusetts.

The last two years have seen a bit of rain, so I'm hoping the weather Gods will play nicely this year since I rashly agreed to join the Staley's Riders team, as did Marian, one lunchtime when we all met up in NY :).

To date, I'm about a third of the way towards my target, so if any of you readers or your organisation would like to chip in for a good cancer cause, here's the link.

It will be interesting to see how effective social media is at helping to fund raise.  All donations are warmly appreciated in advance!

 

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