links for 2009-05-02
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The RNAi pathway is mediated by short double-stranded RNA oligonucleotides called “small interfering RNAs” or “siRNAs.” To date, efforts aimed at harnessing this pathway to silence disease-causing proteins have used double-stranded siRNAs. Using its expertise in oligonucleotide chemistry and design, Isis has discovered strategies for designing single-stranded oligonucleotides that act through the RNAi mechanism. With further development, these chemically modified, single-stranded, RNA-like oligonucleotides could have improved properties for systemic administration while harnessing certain advantages of the RNAi mechanism.
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Explore open source software hotspots around the world through the interactive Open Source Index, or OSI, based on research by the Georgia Institute of Technology (Georgia Tech). The OSI is a measure of the open source activity and environment in 75 countries. Each country is given a score based on its policies, practices, and other data in the fields of Government, Industry, and Community. The leader? France.