Pharma Strategy Blog

Commentary on Pharma & Biotech Oncology / Hematology New Product Development

If we take a look at the IGF-1R pathway shown in the diagram, we can appreciate the sheer size and complexity of tyrosine kinase blocking downstream of the receptor. 

One of the more recent trends that is showing up in clinical trials is to combine an mTOR inhibitor such as everolimus or temsirolimus, with an IGF-1R inhibitor such as NVP-AEW541 (Novartis) or IMC-A12 (ImClone), in solid tumours such as GIST and or liquid tumours such as lymphomas.  The benefits of this strategy may outway the potential downsides, given the ubiquity of IGFR expression.

Another, similar, approach is to combine the mTOR with an EGFR or HER-2 inhibitor.

It remains to be seen whether receptor and downstreaming blocking will add any improvement in efficacy without introducing significant side effects, but intuitively, the approach makes sense and may even lead to a delay in disease progression or the development of resistance.  Indeed, it is possible that patients may respond to different therapies, leading to the identification of new biomarkers for determining a more personalised approach to the treatment of cancer.

Time will tell.

Posted via email from sallychurch’s posterous

One Response to “The complexity of cell signalling pathways in oncology”

  1. The PI3K, MEK and RAS pathways in cancer | Pharma Strategy Blog

    […] The complexity of cell signalling pathways in oncology ( This entry was posted in Market Trends, Mechanism of Action, New products, Oncology, Pathways, Pipeline, Targeted Therapies and tagged Biotechnology marketing, competitive intelligence, KOL market research, landscape opportunity assessments, market surveillance, pharmaceutical strategy consulting, social media monitoring. Bookmark the permalink. ← What Percentage of Physicians Communicate Online With Patients? | iHealthBeat links for 2009-10-06 → blog comments powered by Disqus /* […]

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